TY  - CHAP
M1  - Book, Section
TI  - High-Frequency Oscillatory Ventilation
A1  - Duff, Michael
A1  - Pastores, Stephen M.
A2  - Oropello, John M.
A2  - Pastores, Stephen M.
A2  - Kvetan, Vladimir
PY  - 1
T2  - Critical Care
AB  - KEY  POINTSHigh-frequency  oscillatory  ventilation  (HFOV)  is  a  form  of  ventilatory  support  which  delivers  very  small  tidal  volumes  (1-2  ml  per  kg)  at  very  high  rates  (3-15  breaths  per  second).The  major  indication  for  HFOV  is  for  patients  with  severe  acute  respiratory  distress  syndrome  (ARDS)  whose  lungs  cannot  tolerate  high  tidal  distending  pressure.The  main  determinant  of  oxygenation  during  HFOV  is  the  mPaw  which  is  generally  initiated  at  approximately  5  cm  H2O  greater  than  the  mPaw  noted  during  conventional  ventilation.Carbon  dioxide  removal  during  HFOV  is  directly  propportional  to  the  oscillation  amplitude  and  inversely  proportional  to  the  oscillation  frequency  setting.Two  recent  multicenter  randomized  trials  showed  no  benefit  (OSCAR)  and  even  harm  (OSCILLATE)  with  the  use  of  HFOV  in  adult  patients  with  ARDS.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1136419788
ER  -