TY  - CHAP
M1  - Book, Section
TI  - Diabetes Mellitus
A1  - Kasper, Dennis L.
A1  - Fauci, Anthony S.
A1  - Hauser, Stephen L.
A1  - Longo, Dan L.
A1  - Jameson, J. Larry
A1  - Loscalzo, Joseph
PY  - 2016
T2  - Harrison's Manual of Medicine, 19e
AB  - Diabetes  mellitus  (DM)  comprises  a  group  of  metabolic  disorders  that  share  the  common  feature  of  hyperglycemia.  DM  is  currently  classified  on  the  basis  of  the  pathogenic  process  that  leads  to  hyperglycemia.  Type  1  DM  is  characterized  by  insulin  deficiency  and  a  tendency  to  develop  ketosis,  whereas  type  2  DM  is  a  heterogeneous  group  of  disorders  characterized  by  variable  degrees  of  insulin  resistance,  impaired  insulin  secretion,  and  excessive  hepatic  glucose  production.  Other  specific  types  include  DM  caused  by  genetic  defects  (maturity-onset  diabetes  of  the  young  [MODY]  and  other  rare  monogenic  disorders),  diseases  of  the  exocrine  pancreas  (chronic  pancreatitis,  cystic  fibrosis,  hemochromatosis),  endocrinopathies  (acromegaly,  Cushing’s  syndrome,  glucagonoma,  pheochromocytoma,  hyperthyroidism),  drugs  (nicotinic  acid,  glucocorticoids,  thiazides,  protease  inhibitors),  and  pregnancy  (gestational  DM).  The  phenotype  of  these  monogenetic  and  secondary  types  of  DM  typically  resembles  type  2  DM;  its  severity  depends  on  the  degree  of  beta  cell  dysfunction  and  prevailing  insulin  resistance.  Type  1  DM  usually  results  from  autoimmune  destruction  of  pancreatic  beta  cells;  it  is  also  known  as  juvenile-onset  diabetes  because  its  peak  incidence  is  in  children  and  adolescents.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1137770110
ER  -