TY - CHAP M1 - Book, Section TI - Allogeneic Transplantation A1 - Brammer, Jonathan E. A1 - Andersson, Borje S. A1 - Hosing, Chitra A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. PY - 2016 T2 - The MD Anderson Manual of Medical Oncology, 3e AB - For patients with hematologic malignancies, allogeneic stem cell transplantation (alloSCT) provides potentially curative therapy over standard therapeutic approaches in patients whose disease is incurable with standard chemotherapy. With the development of novel techniques of transplantation, including reduced-intensity conditioning (RIC) and management of transplant-associated toxicities, increasing numbers of patients with advanced age or comorbidities can undergo this potentially lifesaving procedure. According to the most recent statistics from the Center for International Blood and Marrow Transplant Research (CIBMTR), a consortium that collects data from over 400 transplant centers worldwide, over 9,000 patients received alloSCT in 2011, up from 7,500 in 2001 (1). Given the increasing frequency of stem cell transplants worldwide, practitioners need to be familiar with the key concepts regarding the indications, procedures, and management of this technique. This chapter reviews the current state of alloSCT, with particular attention to strategies utilized at the MD Anderson Cancer Center (MDACC). The specific indications for alloSCT are briefly discussed, but a more in-depth discussion of indications is found in chapters covering specific disease states. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1126741233 ER -