TY - CHAP M1 - Book, Section TI - Sickle Cell Disease and Hereditary Hemolytic Anemias A1 - Williams-Johnson, Jean A1 - Williams, Eric A2 - Tintinalli, Judith E. A2 - Stapczynski, J. Stephan A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Cline, David M. PY - 2016 T2 - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e AB - Hereditary anemias result from defects in hemoglobin production, abnormalities in red blood cell (RBC) metabolism, or changes within RBC membrane structure. Increased hemolysis occurs because the RBCs produced are either abnormal or sustain damage after release from the bone marrow, and are removed from the circulation, primarily by the spleen. Depending on the compensatory rate of production, the concentration of circulating erythrocytes may decrease, resulting in anemia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1121494428 ER -