TY  - CHAP
M1  - Book, Section
TI  - Drug Invention and the Pharmaceutical Industry
A1  - Rivera, Suzanne M.
A1  - Gilman, Alfred Goodman
A2  - Brunton, Laurence L.
A2  - Chabner, Bruce A.
A2  - Knollmann, Björn C.
PY  - 2015
T2  - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
AB  - The  first  edition  of  this  textbook,  published  in  1941,  is  often  credited  with  organizing  the  field  of  pharmacology,  giving  it  intellectual  validity  and  an  academic  identity  *.  That  first  edition  began:  "The  subject  of  pharmacology  is  a  broad  one  and  embraces  the  knowledge  of  the  source,  physical  and  chemical  properties,  compounding,  physiological  actions,  absorption,  fate,  and  excretion,  and  therapeutic  uses  of  drugs.  A  drug  may  be  broadly  defined  as  any  chemical  agent  that  affects  living  protoplasm,  and  few  substances  would  escape  inclusion  by  this  definition."  These  two  sentences  still  serve  us  well.  This  first  section  of  the  12th  edition  of  this  textbook  provides  the  underpinnings  for  these  definitions  by  exploring  the  processes  of  drug  invention  and  development  into  a  therapeutic  entity,  followed  by  the  basic  properties  of  the  interactions  between  the  drug  and  biological  systems:  pharmacodynamics,  pharmacokinetics  (including  drug  transport  and  metabolism),  and  pharmacogenomics.  Subsequent  sections  deal  with  the  use  of  drugs  as  therapeutic  agents  in  human  subjects.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2023/04/02
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1127864572
ER  -