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Key Clinical Updates in Gastroesophageal Reflux Disease

The medication vonoprazan (20 mg orally once daily) may be considered in patients with erosive esophagitis or persistent nocturnal heartburn that is unresponsive to PPI therapy.

Laine L et al. Gastroenterology. [PMID: 36228734]

ESSENTIALS OF DIAGNOSIS

  • Heartburn; may be exacerbated by meals, bending, or recumbency.

  • Typical uncomplicated cases do not require diagnostic studies.

  • Endoscopy demonstrates abnormalities in one-third of patients.

GENERAL CONSIDERATIONS

GERD is a condition that develops when the reflux of stomach contents causes troublesome symptoms or complications. Approximately 30% of adults experience GERD symptoms at least weekly. The two most common symptoms are heartburn and regurgitation. However, other symptoms of GERD include dyspepsia, dysphagia, belching, chest pain, cough, hoarseness, and impaired sleep. Although most patients have mild disease, esophageal mucosal damage (reflux esophagitis) develops in up to one-third and more serious complications develop in a few others. Several factors may contribute to GERD.

A. Dysfunction of the Gastroesophageal Junction

The antireflux barrier at the gastroesophageal junction (eFigure 17–4) depends on LES pressure, the intra-abdominal location of the sphincter (resulting in a “flap valve” caused by angulation of the esophageal-gastric junction), and the extrinsic compression of the sphincter by the crural diaphragm. Although most patients with GERD have normal LES pressures, a subset have an incompetent LES that results in increased acid reflux, especially when supine or when intra-abdominal pressures are increased by lifting or bending. A hypotensive sphincter is present in up to 50% of patients with severe erosive GERD.

eFigure 17–4.

Normal appearing "Z line": the junction of squamous esophageal mucosa and columnar gastric mucosa. (Used, with permission, from Y. Chen.)

Hiatal hernias are found in one-fourth of patients with nonerosive GERD, three-fourths of patients with severe erosive esophagitis, and over 90% of patients with Barrett esophagus. They are caused by movement of the LES above the diaphragm, resulting in dysfunction of the gastroesophageal junction reflux barrier. Hiatal hernias are common and may cause no symptoms (eFigure 17–5); however, in patients with gastroesophageal reflux, they are associated with higher amounts of acid reflux and delayed esophageal acid clearance, leading to more severe esophagitis and Barrett esophagus. Increased reflux episodes occur during normal swallowing-induced relaxation, transient LES relaxations, and straining due to reflux of acid from the hiatal hernia sac into the esophagus.

eFigure 17–5.

With gastroscope within stomach and retroflexed, the proximal stomach can be seen extending above the diaphragmatic narrowing. (Used, with permission, from Y. Chen.)

Truncal obesity may contribute to GERD, presumably due to an increased intra-abdominal pressure, which contributes to dysfunction of the gastroesophageal junction and increased likelihood of hiatal hernia.

B. Irritant ...

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