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LYME DISEASE (LYME BORRELIOSIS)
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When assessing for CNS Lyme disease in an appropriate clinical syndrome, serum antibody testing is recommended over cerebrospinal fluid serology or PCR.
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While serology is recommended to diagnose Lyme arthritis, PCR can be done on synovial fluid or tissue if needed to confirm the diagnosis and guide treatment.
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Lantos PM et al. Clin Infect Dis. [PMID: 33417672]