| Gastrointestinal | Abdominal pain, bleeding, constipation, diarrhea, dyspepsia, dysphagia, eructation,b esophageal stricture/ulceration, esophagitis, flatulence, gastritis, hematemesis,b melena,b nausea, odynophagia, perforation, pyrosis, stomatitis, ulcers, vomiting, xerostomiab |
| Platelets | Inhibited platelet activation,b propensity for bruising,b increased risk of hemorrhage,b platelet dysfunction,b thrombocytopeniab |
| Renal | Azotemia,b cystitis,b dysuria,b hematuria, hyponatremia, interstitial nephritis, nephrotic syndrome,b oliguria,b polyuria,b renal failure, renal papillary necrosis, proteinuria, salt and water retention, hypertension, worsening of renal function in renal/cardiac/cirrhotic patients, effectiveness of antihypertensives and diuretics, hyperkalemia,b ↓ urate excretion (especially with aspirin) |
| Cardiovascular | Edema,b heart failure,c hypertension, MI,c palpitations,b premature closure of ductus arteriosus, sinus tachycardia,b stroke,c thrombosis,c vasculitisb |
| Neurologic | Anorexia,b anxiety,b aseptic meningitis, confusion,b depression, dizziness, drowsiness,b headache, insomnia,b malaise,b paresthesias, tinnitus, seizures,b syncope,b vertigob |
| Reproductive | Prolongation of gestation, inhibition of labor, delayed ovulation |
| Hypersensitivity | Anaphylactoid reactions, angioedema, severe bronchospasm, urticaria, flushing, hypotension, shock |
| Hematologic | Anemia, agranulocytosis, aplastic anemia,b hemolytic anemia,b leukopeniab |
| Hepatic | Elevated enzymes, hepatitis, hepatic failure,b jaundice |
| Dermatologic | Diaphoresis,b exfoliative dermatitis, photosensitivity,b pruritus, purpura,b rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria |
| Respiratory | Dyspnea,b hyperventilation (salicylates) |
| Other | Alopecia,b blurred vision,b conjunctivitis,b epistaxis,b fever,b hearing loss,b pancreatitis,b paresthesias, visual disturbance,b weight gainb |