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The goals of therapy for type 1 or type 2 diabetes mellitus (DM) are to (1) eliminate symptoms related to hyperglycemia, (2) reduce or eliminate the long-term microvascular and macrovascular complications of DM (Chap. 405), and (3) allow the patient to achieve as normal a lifestyle as possible. To reach these goals, the physician should identify a target level of glycemic control for each patient, provide the patient with the educational and pharmacologic resources necessary to reach this level, and monitor/treat DM-related complications. Symptoms of diabetes usually resolve when the plasma glucose is <11.1 mmol/L (200 mg/dL), and thus most DM treatment focuses on achieving the second and third goals. This chapter first reviews the ongoing treatment of diabetes in the outpatient setting and then discusses the treatment of severe hyperglycemia, as well as the treatment of diabetes in hospitalized patients.

The care of an individual with either type 1 or type 2 DM requires a multidisciplinary team. Central to the success of this team are the patient’s participation, input, and enthusiasm, all of which are essential for optimal diabetes management. Members of the health care team usually include the primary care provider and/or the endocrinologist or diabetologist, a certified diabetes educator, a nutritionist, a psychologist, and possibly a social worker. In addition, when the complications of DM arise, subspecialists (including ophthalmologists, neurologists, podiatrists, nephrologists, cardiologists, and cardiovascular surgeons) with experience in DM-related complications are essential.


A number of names are sometimes applied to different approaches to diabetes care, such as intensive insulin therapy, intensive glycemic control, and “tight control.” The current chapter, and other sources, uses the term comprehensive diabetes care to emphasize the fact that optimal diabetes therapy involves more than glucose management and medications and is patient-centered and individualized as advocated by the American Diabetes Association (ADA). Although glycemic control is central to optimal diabetes therapy, comprehensive diabetes care of both type 1 and type 2 DM should also detect and manage DM-specific complications (Chap. 405), and modify risk factors for DM-associated diseases. The key elements of comprehensive diabetes care are summarized in Table 404-1. The morbidity and mortality of DM can be greatly reduced by timely and consistent surveillance, including the detection, prevention, and management of DM-related complications (Table 404-1 and Chap. 405). Such screening procedures are indicated for all individuals with DM, but many individuals with diabetes do not receive these or comprehensive diabetes care. In addition to the physical aspects of DM, social, family, financial, cultural, and employment-related issues may impact diabetes care. The treatment goals for patients with diabetes summarized in Table 404-2 should be individualized. The prevention and treatment of clinically significant hypoglycemia (<3.0 mmol/L or 54 mg/dL) is discussed in Chap. 406. This chapter, while recognizing that resources available for diabetes ...

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