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Immunobiologicals, Cytokines, and Growth Factors at a Glance
  • Immunobiologicals are drugs, defined as compounds engineered from living organisms that induce or alter immune responses by interacting with specific biologic targets.
  • Used to treat conditions with immune abnormalities.
  • Those used to treat cutaneous disease include recombinant cytokines and growth factors, monoclonal antibodies, and fusion proteins.
  • Targeting the immune system with biologics may result in an increased risk of infections and malignancies.

Immunobiologicals are compounds synthesized in living organisms that exhibit immune modulatory properties. They consist of recombinant cytokines, growth factors, antibody-based agents, and fusion proteins. Those with dermatologic indications are discussed in this chapter and are listed in Table 234-1. Fig. 234-1 illustrates the molecular targets of these compounds. Fig. 234-2 depicts the cellular events that mediate cutaneous inflammation and identifies the molecular interactions affected by specific immunobiological agents.

Table 234-1 Immunobiologicals, Cytokines, and Growth Factors

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