Pain at the injection site can occur (use larger veins or premedicate with lidocaine).
Anaphylaxis, hypotension, bradycardia, supraventricular tachydysrhythmias, conduction disturbances, cough, bronchospasm, rash, pruritus, and hyperlipidemia may occur.
Anesthetic doses require respiratory support. Avoid rapid bolus doses because of the higher risk for hypotension, bradycardia, apnea, and airway obstruction.
Anesthetic doses may be associated with myoclonus, posturing, and seizure-like movement phenomena (jerking, thrashing). Seizures have been noted when patients were weaned from propofol.
Propofol infusion syndrome, a condition of metabolic acidosis, hyperkalemia, lipemia, renal failure, rhabdomyolysis, hepatomegaly, and cardiovascular collapse, has been associated most often ...