Hypersensitivity reactions: rash, pruritus, drug fever, hematuria, antinuclear antibodies, and proteinuria.
Leukopenia, thrombocytopenia, hemolytic anemia, aplastic anemia, and agranulocytosis.
Hepatitis and pancreatitis.
Anorexia, nausea, vomiting, epigastric pain, and impairment of taste.
The requirement for pyridoxine is increased, and the patient may require daily supplementation (See Pyridoxine (Vitamin B6)).
Use in pregnancy. Birth defects have been associated with use during pregnancy. No assigned FDA category (See Introduction in Section III).