Additive sedation in the presence of other CNS depressants.
Risk for extrapyramidal reactions may be increased in the presence of other dopamine antagonist agents (eg, haloperidol and phenothiazines).
In one study involving hypertensive patients, metoclopramide enhanced the release of catecholamines. As a result, the manufacturer advises cautious use in hypertensive patients and suggests that the drug should not be used in patients taking monoamine oxidase inhibitors.
Agitation, diaphoresis, and extrapyramidal movement disorder were reported in two patients taking selective serotonin reuptake inhibitors (sertraline, venlafaxine) who received IV metoclopramide.
The drug may enhance the absorption of ingested drugs by promoting gastric emptying.
Anticholinergic agents may inhibit bowel motility effects.
Numerous IV incompatibilities: calcium gluconate, sodium bicarbonate, cimetidine, furosemide, and many antibiotic agents (eg, ampicillin, chloramphenicol, erythromycin, penicillin G potassium, tetracycline).