Anxiety, agitation, headache, dizziness, nausea, vomiting, tremor, and transient facial flushing.
Rapid reversal of benzodiazepine effect in high-tolerance patients, such as those with benzodiazepine addiction or chronic use, especially if they have a history of seizures, may result in an acute withdrawal state, including hyperexcitability, tachycardia, and seizures.
Seizures or arrhythmias may be precipitated in patients with a serious tricyclic antidepressant or other proconvulsant overdose.
Flumazenil has precipitated arrhythmias in a patient with mixed benzodiazepine and chloral hydrate overdose.
Other risks include re-sedation and aspiration.
Use in pregnancy. FDA Category C (indeterminate). This does not preclude its acute, short-term use for a seriously symptomatic patient (See Introduction in Section III).