Skip to Main Content

++

Selenium exists in four natural oxidation states (+6, +4, 0, and –2) and is found in several compounds capable of causing human poisoning, yet it is an essential trace element in the human diet. Table II–54 describes the chemistry of selenium compounds. Fatal acute selenium poisoning occurs most commonly from ingestion of selenious acid in gun bluing (coating) solutions. Other acute poisonings occur through the use of (often improperly formulated) dietary supplements as well as via exposure to industrial compounds. Illness caused by chronic exposure to selenium is uncommon but is seen in regions with high selenium content in food. Industries using selenium compounds include ceramics, electronics, glass, rubber, and metallurgy. Selenium dioxide is the most commonly used compound industrially. Selenium is produced largely as a by-product of copper refining.

++
Table Graphic Jump Location
Table II-54 Selenium Compounds
++

  1. Mechanism of toxicity. Precise cellular toxopathology is poorly understood. Animal studies implicate mechanisms involving the formation of superoxide and hydroxyl anions as well as hydrogen peroxide. Mechanistic knowledge makes no contribution to treatment currently. A garlic breath odor observed in various selenium poisonings is due to in vivo creation of dimethyl selenium.

  2. Toxic dose

    1. Ingestion

      1. Acute overdose. Rapidly fatal overdoses have occurred from ingestion of gun bluing solutions containing 2–9% selenious acid and 2–4% copper. Ingestion of 15 mL of gun bluing solution containing 4% selenious acid was fatal. The oral mean lethal dose (MLD) of selenite salts in the dog is about 4 mg/kg. Ingestion of 1–5 mg/kg sodium selenite in five adults ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.