The regional musculoskeletal examinations (RMSE) of the shoulder, knee, neck, and low back are designed to build on the sequences and techniques of the SMSE and GMSE. They are intended to provide comprehensive assessments of structure and function combined with special testing to permit evaluation of common, important musculoskeletal problems in the shoulder, knee, neck, and low back. The skills involved require practice and careful attention to technique; however, they can be learned and mastered on normal individuals. The RMSEs are clinically useful as the initial examination in individuals whose history clearly suggests a local or regional musculoskeletal problem of the shoulder, knee, neck, or low back. With practice, a systematic, efficient RMSE can be performed in ∼3 to 4 minutes.