Goldenberg RL, Mwatha A, Read JS, et al; Hptn024
Team. The HPTN 024 Study: The efficacy of antibiotics to prevent
chorioamnionitis and preterm birth.
Am J Obstet Gynecol 2006;194:650–661.
[PubMed: 16522393]
(Despite reducing the rate of vaginal infections,
the antibiotic regimen [oral
metronidazole, 250 mg, and
oral
erythromycin, 250 mg, three times daily for 7 days at 24 weeks’ gestation
and
metronidazole, 250 mg, and
ampicillin, 500 mg, every 4 hours
during labor] used in this study did not reduce the rate
of preterm birth, increase the time to delivery, or increase birth
weight. Failure of this regimen to reduce the rate of histologic
chorioamnionitis may explain the reason the antibiotics failed to
reduce preterm birth.)