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The cluster of differentiation (CD) antigens are cellular molecules that are each recognized by monoclonal antibodies (mAbs) that allow for the identification of each molecule’s biochemical properties and cellular distribution. The CD number for each molecule is defined at international workshops that exchange such mAbs and compare their ability to react with human cells and/or human cell molecules. This chapter provides an overview of the approximately 350 CD antigens defined as of the eighth international workshop, listing the other names for these CD antigens along with their biochemistry, membrane-orientation, genetics, cellular distribution, and physiology.

Acronyms and Abbreviations

Acronyms and abbreviations that appear in this chapter include: act., activated; ADAM, a disintegrin and metalloprotease; AF, accessory factor; Ag, antigen; ALK, anaplastic lymphoma kinase; ALL, acute lymphocytic leukemia; APC, antigen-presenting cell; APO-1, apoptosis antigen ligand-1; APRIL, a proliferation-inducing ligand; ART1, ADP-ribosyltransferase 1; BAFF, B-cell activating factor of the tumor necrosis factor family; BCMA, B-cell maturation antigen; BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; C-type lectin, Ca2+-dependent lectin; CA, carcinoma; Ca2+, ionized calcium; CALLA, common acute leukemia antigen; CCR, chemokine C-C motif receptor; CD, cluster of differentiation; CEA, carcinoembryonic antigen; CMRF, epitope recognized by the CMRF-35 mAB; CMV, cytomegalovirus; CNS, central nervous system; CRTH2, chemoattractant receptor-homologous molecule; CTL, cytotoxic T lymphocytes; CTLA-4, cytotoxic T-lymphocyte–associated protein-4; CXCR, chemokine CXC motif receptor; DAF, decay accelerating factor; DC, dendritic cell; DNAM, DNAX accessory molecule; ELAM, endothelial leukocyte adhesion molecule; eos, eosinophil; EBV, Epstein-Barr virus; ECM, extracellular matrix; esp., especially; FDC, follicular dendritic cells; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; GC, germinal center; G-CSF, granulocyte colony-stimulating factor; GI, gastrointestinal; GM-CSF, granulocyte-macrophage colony-stimulating factor; gp, glycoprotein; GPI, glycosylphosphatidylinositol; HA, hyaluronan; HCL, hairy cell leukemia; hsp, heat shock protein; Hep., heptaspan; HEV, high endothelial venules; HGM-CSFR, human granulocyte-macrophage colony-stimulating factor; HIgR, herpesvirus immunoglobulin-like receptor; HIV, human immunodeficiency virus; HLA, human leukocyte antigen; HML, human mucosal lymphocyte; HSC, hematopoietic stem cells; HSV, herpes simplex virus; IAP, integrin associated protein; ICAM, intercellular adhesion molecule; IEL, intraepithelial lymphocytes; IFN, interferon; IGF, insulin-like growth factor; IgSF, immunoglobulin superfamily; IL, interleukin; ILT, immunoglobulin-like transcript; IRF3, interferon regulatory factor 3; IRTA, immunoglobulin superfamily receptor translocation associated; ITAM, immune tyrosine-based activating motifs; ITGAE, integrin alpha E; ITIM, immune tyrosine-based inhibitory motifs; ITSM, immune tyrosine-based switch motifs; JAM, junctional adhesion molecule-1; KIR, killer cell inhibitory receptor; LAMP, lysosomal membrane-associated glycoprotein; LARC, liver and activation-regulated chemokine; LDL, low-density lipoprotein; LECAM, leukocyte endothelial cell adhesion molecule; LFA, leukocyte function antigen; LGL, large granular lymphocyte; LIF, leukemia inhibitory factor; LIR, leukocyte immunoglobulin-like receptor; LPS, lipopolysaccharide; mAb, monoclonal antibody; MCP, monocyte chemoattractant protein; MDR, multidrug resistance; MHC, major histocompatibility complex; MICA, major histocompatibility complex class I chain A; MICB, major histocompatibility complex class I chain B; MIP-1, macrophage inflammatory protein; MMP, matrix metalloproteinase; MRP, mobility-related protein; MSP, macrophage-stimulating protein; MSP-R, macrophage-stimulating protein receptor; MUC-1, mucin-1; MØ, macrophages; NCAM, neural cell adhesion molecule; NF-κB, nuclear factor-kappa B; NK, natural killer; O, orientation/anchorage of the antigen in the ...

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