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Optic disk swelling may result from any orbital lesion causing nerve compression, severe hypertensive retinochoroidopathy, or raised intracranial pressure, the last necessitating urgent imaging to exclude an intracranial mass, hemorrhage, infection, or cerebral venous sinus occlusion. Intraocular causes of optic disk swelling include central retinal vein occlusion, posterior uveitis, and posterior scleritis. Optic nerve lesions causing disk swelling include anterior ischemic optic neuropathy; optic neuritis; optic nerve sheath meningioma; and infiltration by sarcoidosis, leukemia, or lymphoma.
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Papilledema (optic disk swelling due to raised intracranial pressure) is usually bilateral and most commonly produces enlargement of the blind spot without loss of acuity (eFigure 7–66) (eFigure 7–67). Severe acute papilledema or chronic papilledema, as in idiopathic intracranial hypertension and cerebral venous sinus occlusion, may be associated with visual field and occasionally with profound visual acuity loss (eFigure 7–68). All patients with chronic papilledema must be monitored carefully—especially their visual fields—and CSF shunt or optic nerve sheath fenestration should be considered in those with progressive visual loss not controlled by medical therapy (weight loss where appropriate and usually acetazolamide in patients with idiopathic intracranial hypertension). In idiopathic intracranial hypertension, transverse venous sinus stenting is also an option for patients with progressive vision loss.
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Optic disk drusen and congenitally crowded optic disks, which are associated with farsightedness, cause optic disk elevation that may be mistaken for swelling (pseudo-papilledema). Exposed optic disk drusen may be obvious clinically or can be demonstrated by their autofluorescence. Buried drusen are best detected by orbital ultrasound or CT scanning. Other family members may be similarly affected.
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Bouthour
W
et al. Diagnosis of optic disc oedema: fundus features, ocular imaging findings, and artificial intelligence. Neuroophthalmology. 2023;47:177.
[PubMed: 37434667]
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Spiegel
SJ
et al. Neuro-ophthalmic emergencies. Neurol Clin. 2021;39:631.
[PubMed: 33896536]