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Sympatholytic antihypertensives are central alpha-2-adrenergic agonists
Clonidine
Guanabenz
Guanfacine
Methyldopa
Symptoms usually resolve in 24 hours
Death is rare
Similar symptoms may occur after application of topical nasal decongestants chemically similar to clonidine; for example
Oxymetazoline
Tetrahydrozoline
Naphazoline
Brimonidine
Apraclonidine
Tizanidine
Xylazine
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