Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content ++ For further information, see CMDT Part 14-06: Congenital Disorders of Platelet Function +++ Key Features ++ Group of mild bleeding disorders caused by defects in release of alpha or dense (delta) platelet granules, or both +++ Clinical Findings ++ Variable bleeding, ranging from spontaneous to mild and trauma-related bruising to postoperative bleeding +++ Diagnosis ++ Prolonged bleeding time Platelet aggregation studies characteristically show platelet dissociation following an initial aggregatory response Electron microscopy confirms diagnosis +++ Treatment ++ Mainstay of treatment (including periprocedural prophylaxis) is transfusion of normal platelets Desmopressin acetate (DDAVP), antifibrinolytic agents, and recombinant human activated factor VII also have been used successfully Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.