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Potential food or drug interactions can occur during therapeutic use
Ingestion of tyramine-containing foods (eg, aged cheese and red wines) or any sympathomimetic drug may cause a severe hypertensive reaction
Severe or fatal hyperthermia (serotonin syndrome)
May occur when monoamine oxidase inhibitors (MAOIs) are given with serotonin-enhancing drugs (eg, meperidine, fluoxetine, paroxetine, fluvoxamine, venlafaxine, tryptophan, dextromethorphan, tramadol)
Can also occur with moclobemide (an MAOI not available in the United States) and linezolid, which has MAOI properties
Can also occur with selective serotonin reuptake inhibitors (SSRIs) in large doses or in combination with other SSRIs, even in the absence of an MAOI or meperidine
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