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  • Fluctuating throat or mouth discomfort.

  • Associated with systemic or local immunosuppression, such as recent corticosteroid, chemotherapy, or antibiotic use.

  • Erythema of the oral cavity or oropharynx with creamy-white, curd-like patches.

  • Rapid resolution of symptoms with appropriate treatment.


A. Symptoms and Signs

Oral candidiasis (thrush) is usually painful and looks like creamy-white curd-like patches overlying erythematous mucosa (see Figure 6–11). Because these white areas are easily rubbed off (eg, by a tongue depressor)—unlike leukoplakia or lichen planus—only the underlying irregular erythema may be seen. Oral candidiasis is commonly associated with the following risk factors: (1) use of dentures, (2) debilitated state with poor oral hygiene, (3) diabetes mellitus, (4) anemia, (5) chemotherapy or local irradiation, (6) corticosteroid use (oral or systemic), or (7) broad-spectrum antibiotics. Another manifestation of candidiasis is angular cheilitis (also seen in nutritional deficiencies) (Figure 8–8).

Figure 8–8.

Severe angular cheilitis in HIV-positive man with oral thrush. (Reproduced with permission from Richard P. Usatine, MD, in Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H. The Color Atlas of Family Medicine, 2nd ed. McGraw-Hill, 2013.)

B. Diagnostic Studies

The diagnosis is made clinically. A wet preparation using potassium hydroxide will reveal spores and may show nonseptate mycelia. Biopsy will show intraepithelial pseudomycelia of Candida albicans.

Candidiasis is often the first manifestation of HIV infection, and HIV testing should be considered in patients with no known predisposing cause for Candida overgrowth (see also Chapter 31). The US Department of Health Services Clinical Practice Guideline for Evaluation and Management of Early HIV Infection recommends examination of the oral mucosa with each clinician visit as well as at a dental examination every 6 months for individuals living with HIV.


Effective antifungal therapy may be achieved with any of the following: fluconazole (100 mg orally daily for 7 days), ketoconazole (200–400 mg orally with breakfast [requires acidic gastric environment for absorption] for 7–14 days), clotrimazole troches (10 mg dissolved orally five times daily), or nystatin mouth rinses (500,000 units [5 mL of 100,000 units/mL] held in the mouth before swallowing three times daily). In patients with HIV infection, however, longer courses of therapy with fluconazole may be needed, and oral itraconazole (200 mg/day) may be indicated in fluconazole-refractory cases. Many of the Candida species in these patients are resistant to first-line azoles and may require newer medications, such as voriconazole. In addition, 0.12% chlorhexidine or half-strength hydrogen peroxide mouth rinses may provide local relief. Nystatin powder (100,000 units/g) applied to dentures three or four times daily and rinsed off for several weeks may help denture wearers.

Fang  J  et al. Efficacy ...

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