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Most vaccines are safe to administer. In general, it is recommended that the use of live vaccines be avoided in immunocompromised patients, including pregnant women. Vaccines are generally not contraindicated in the following situations: mild, acute illness with low-grade fevers (less than 40.5°C); concurrent antibiotic therapy; soreness or redness at the site; and family history of adverse reactions to vaccinations. Absolute contraindications to vaccines are rare (Table 30–8).

Table 30–8.Adverse effects and contraindications to commonly used vaccines in adults (listed in alphabetical order).

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