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Clinical trials have suggested an increase in all-cause mortality with high dose (greater than 400 IU/day) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and result in bleeding in patients taking oral anticoagulants.

Sherf-Dagan  S  et al. Vitamin E status among bariatric surgery patients: a systematic review. Surg Obes Relat Dis. 2021;17:816.
[PubMed: 33323330]  

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