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Daily parenteral maintenance fluids and electrolytes for an average adult of 70 kg would include at least 2 L of water in the form of 0.45% saline with 20 mEq/L of potassium chloride. Patients with hypoglycemia, starvation ketosis, or ketoacidosis being treated with insulin may require 5% dextrose-containing solutions. Guidelines for GI fluid losses are shown in Table 21–17.

Table 21–17.Replacement guidelines for sweat and GI fluid losses.

Weight loss or gain is the best indication of water balance. Insensible water loss should be considered in febrile patients. Water loss increases by 100–150 mL/day for each degree of body temperature over 37°C.

In patients requiring maintenance and possibly replacement of fluid and electrolytes by parenteral infusion, the total daily ration should be administered continuously over 24 hours to ensure optimal utilization.

If intravenous fluids are the only source of water, electrolytes, and calories for longer than a week, parenteral nutrition containing amino acids, lipids, trace metals, and vitamins may be indicated. (See Chapter 29.)

Balanced crystalloid-like lactated Ringer solution, rather than normal saline, is the resuscitation fluid of choice in most settings (see Chapter 12). Excessive fluid resuscitation and maintenance are complications in hospitalized patients, especially those with critical illness or AKI. These complications have been associated with worsened outcomes, such as prolonged mechanical ventilation, dependence on dialysis, and longer hospitalization with increased mortality.

Moritz  ML  et al. Maintenance intravenous fluids in acutely ill patients. N Engl J Med. 2015;373:1350.
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Vincent  JL. Fluid management in the critically ill. Kidney Int. 2019;96:52.
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Yoo  MS  et al. Association of positive fluid balance at discharge after sepsis management with 30-day readmission. JAMA Netw Open. 2021;4:e216105.
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