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When assessing for CNS Lyme disease in an appropriate clinical syndrome, serum antibody testing is recommended over cerebrospinal fluid serology or PCR.

While serology is recommended to diagnose Lyme arthritis, PCR can be done on synovial fluid or tissue if needed to confirm the diagnosis and guide treatment.

Lantos PM et al. Clin Infect Dis. [PMID: 33417672]

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