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AFRICAN TRYPANOSOMIASIS (SLEEPING SICKNESS)

Fexinidazole is recommended by the World Health Organization as first-line therapy and is FDA-approved for treatment of early and advanced (CNS) West African disease.

Hidalgo J et al. Cureus. [PMID: 34513456]

LEISHMANIASIS

Alternative therapies increasingly used to treat cutaneous leishmaniasis are miltefosine, which benefits from oral dosing and relatively little toxicity, and amphotericin B, which is widely available.

Machado PRL et al. Clin Infect Dis. [PMID: 32894278]

MALARIA

Artemisinin resistance is mediated by any of a series of mutations in the Plasmodium falciparum kelch (K13) gene; of great concern, these same mutations and evidence for delayed clearance after treatment with artemisinins were reported in East Africa in 2021.

Balikagala B et al. N Engl J Med. [PMID: 34551228]

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