Most RCTs evaluating the effects of yoga on cancer patients have exclusively enrolled patients with breast cancer. The early studies are heterogeneous and have various methodologic shortcomings; however, there have been higher quality studies more recently. Overall, the psychological outcomes in these studies are consistent in showing benefits of medium effect sizes. A 2021 systematic review and meta-analysis of yoga for depression and anxiety symptoms yielded 26 studies (n=1486) for depression and 16 studies (n=977) for anxiety. Meta-analyses found significant medium effects for depression and anxiety. Physical outcomes are less consistent and demonstrate smaller effect sizes. Fatigue has been studied in multiple RCTs, and a systematic review concluded: "Yoga may be beneficial for reducing cancer-related fatigue in women with breast cancer; however, conclusions should be interpreted with caution as a result of bias and inconsistent methods used across studies." A 2020 systematic review and meta-analysis of 24 studies found small to medium improvements in cancer-related fatigue in women with breast cancer. A 2021 systematic review and meta-analysis of 26 studies (n=2069) found significant improvements in quality of life in women with breast cancer, including social, emotional, and functional well-being. Most effects have been assessed only in the short term; long-term effects are not well known. Low-intensity forms of yoga, specifically gentle hatha and restorative, are feasible, safe, and effective for treating sleep disruption, cancer-related fatigue, cognitive impairment, psychosocial distress, and musculoskeletal symptoms in cancer patients receiving chemotherapy and radiation and cancer survivors.
A 2019 systematic review and meta-analysis found that yoga had a modest but clinically relevant reduction in blood pressure (systolic blood pressure: −5.0 mm Hg; diastolic blood pressure: −3.9 mm Hg). The greatest benefits were seen when breathing techniques and meditation/mental relaxation were included. Yoga has been consistently superior to no treatment but has not been clearly superior to aerobic exercise. The efficacy of yoga in the secondary prevention of CAD is still under evaluation.
A 2020 systematic review of 18 trials with chronic low back pain concluded that there is low to moderate certainty evidence that yoga results in small to moderate improvements in pain at up to 7 months; it was not shown whether yoga was superior to physical therapy exercises for back pain. A systematic review and meta-analysis concluded that there was strong evidence for short-term and long-term benefit on pain, reduced back-specific disability, and increased global improvement and moderate evidence for a long-term benefit on back-specific disability. An additional RCT concluded that a 6-week yoga intervention is a cost-effective early treatment for low back pain. No serious adverse events occurred in any of these studies.
A systematic review and meta-analysis of 11 RCTs of 586 COPD patients found that yoga training significantly improved forced expiratory volume in 1 second (FEV1), 6-minute walking distance, and quality of life measures. This review suggests that yoga breathing technique can be an effective adjunct intervention for patients with COPD.