Skip to Main Content

INTRODUCTION

Tables AII–1 and AII–2 present a perspective on drug-drug interactions as examined by the effect that one drug (the perpetrator) can have on the area under the plasma concentration versus time curve (AUC) of another drug (the victim). The cutoff value of 5-fold change in the AUC of the victim drug was chosen in order to focus these tables on clinically significant drug-drug interactions that would generally contraindicate the coadministration of the drugs or at least require dosage adjustment.

TABLE AII–1DRUG-DRUG INTERACTIONS WITH AT LEAST 5-FOLD CHANGE IN EXPOSURE OF VICTIM DRUG: SENSITIVE SUBSTRATES
TABLE AII–2DRUG-DRUG INTERACTIONS WITH AT LEAST 5-FOLD CHANGE IN EXPOSURE OF VICTIM DRUG: STRONG INHIBITORS AND INDUCERS

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.