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Part IV. Clinical Virology

Your patient is a 30-year-old man who has frequent episodes of herpes labialis. He asks you to tell him something about herpes simplex virus type 1 (HSV-1). Which one of the following would be the most accurate statement to make?

(A) Acyclovir can eradicate the latent state of HSV-1 but not HSV-2.

(B) The main site of latency by HSV-1 is the neurons in the sensory ganglia of the face.

(C) HSV-1 is an enveloped virus that has a DNA genome and a DNA polymerase in the virion.

(D) The lesions of primary HSV-1 infections are less extensive and less severe than the lesions of recurrent HSV-1 infections.

(E) The laboratory diagnosis of HSV-1 infections typically involves the detection of a greater than fourfold rise in antibody titer against the virus.

Your patient is a woman who is due to give birth next week. She asks you about the risk of her baby becoming infected with herpes simplex virus type 2 (HSV-2). Which one of the following is the most accurate response?

(A) HSV-2 is a significant cause of congenital abnormalities.

(B) The risk is higher if the mother has visible lesions than if she does not.

(C) The risk is higher if the mother has IgG antibody to HSV-2 than if she has IgM antibody.

(D) The risk is higher if the delivery occurs by cesarean section than if the delivery is performed vaginally.

(E) The risk is higher if the mother is having an episode of recurrent disease caused by HSV-2 than if it were a primary episode.

Regarding varicella-zoster virus (VZV), which one of the following is most accurate?

(A) High-dose acyclovir can eliminate the latent state caused by VZV.

(B) The principal site of latency of VZV is in the nucleus of motor neurons.

(C) Domestic animals, such as pigs and chickens, are the main reservoir for VZV.

(D) The vaccine against varicella contains all three serotypes of formalin-killed VZV as the immunogen.

(E) When zoster occurs in an immunocompromised patient, acyclovir should be given to prevent disseminated infection.

Regarding cytomegalovirus (CMV), which one of the following is most accurate?


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