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Fungal Diseases

A young Phoenix woman has developed fever, cough, and after 1 month of illness has an infiltrate in the upper lobe of her right lung. A sputum specimen digested with KOH was negative but the culture grew a mold with alternating arthroconidia.

This infection was most likely acquired by inhalation of:

A. Spherules

B. Yeasts

C. Sexual, macroconidia

D. Asexual, arthroconidia

E. Asexual chlamydoconidia


A young woman who recently moved to Arizona has developed fever and malaise which have lasted for 3 weeks. Her chest radiograph is clear and her physician has diagnosed “valley fever.” Which of the following tests, using a specific preparation of the infecting agent, would raise the greatest concerns about her disease disseminating outside the lung?

A. Positive skin test

B. High levels of IgG antibody

C. Absent IgM antibody

D. Absent IgG antibody

E. High levels of capsular antigen


A young woman has developed fever and diffuse pulmonary infiltrates 1 week after undergoing a bone marrow transplant. She is on immunosuppressive therapy. Material collected in a bronchoalveolar lavage has demonstrated septate branching hyphae and she was placed on amphotericin B. The target of this therapy is:

A. Cell wall mannoprotein

B. Nucleic acids

C. Cytoplasmic membrane

D. Mitotic spindle fibers

E. Cell wall glucan


You are asked to evaluate the antifungal therapy of a patient with an enlarged liver and spleen. The laboratory finding shows that culture of a lymph node biopsy yielded a small (4 mm) yeast at 35°C, which at 25°C grew as a mold with tuberculate macroconidia. The patient most probably acquired this infection in:

A. Semitropical regions of North and South America

B. Ohio and Mississippi River valleys

C. Arid deserts of America and Africa

D. Lower Sonoran life zone

E. Worldwide



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