A young Phoenix woman has developed fever, cough, and after 1 month of illness has an infiltrate in the upper lobe of her right lung. A sputum specimen digested with KOH was negative but the culture grew a mold with alternating arthroconidia.
This infection was most likely acquired by inhalation of:
D. Asexual, arthroconidia
E. Asexual chlamydoconidia
A young woman who recently moved to Arizona has developed fever and malaise which have lasted for 3 weeks. Her chest radiograph is clear and her physician has diagnosed “valley fever.” Which of the following tests, using a specific preparation of the infecting agent, would raise the greatest concerns about her disease disseminating outside the lung?
B. High levels of IgG antibody
E. High levels of capsular antigen
A young woman has developed fever and diffuse pulmonary infiltrates 1 week after undergoing a bone marrow transplant. She is on immunosuppressive therapy. Material collected in a bronchoalveolar lavage has demonstrated septate branching hyphae and she was placed on amphotericin B. The target of this therapy is:
A. Cell wall mannoprotein
D. Mitotic spindle fibers
You are asked to evaluate the antifungal therapy of a patient with an enlarged liver and spleen. The laboratory finding shows that culture of a lymph node biopsy yielded a small (4 mm) yeast at 35°C, which at 25°C grew as a mold with tuberculate macroconidia. The patient most probably acquired this infection in:
A. Semitropical regions of North and South America
B. Ohio and Mississippi River valleys
C. Arid deserts of America and Africa
D. Lower Sonoran life zone