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Most common cause: alcoholism
Other causes
Thiamine depletion can be precipitated when patients with low thiamine are given a large carbohydrate load, such as an intravenous dextrose infusion
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Thiamine, 50–100 mg intravenously for the first few days, followed by 5–10 mg once daily orally
Therapeutic doses of other water-soluble vitamins
Treatment results in complete resolution of symptoms and signs in 50% of patients (one-fourth immediately and one-fourth over days); the remaining 50% obtain only partial resolution or no benefit