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Key Features

Essentials of Diagnosis

  • Recurrent, variable cluster of troublesome physical and emotional symptoms that develops during the 5 days before the onset of menses

  • Symptoms subside within 4 days after menstruation occurs

  • In about 10% of affected women, the syndrome may be severe

General Considerations

  • The pathogenesis is still uncertain. Psychosocial factors may play a role

  • Suppression of ovulation with an oral contraceptive is sometimes helpful, but the patient often complains that she still has premenstrual syndrome


  • Intermittently affects about one-third of all premenopausal women, primarily those 25–40 years of age

Clinical Findings

Symptoms and Signs

  • Women may not experience all the symptoms or signs at one time

  • Bloating

  • Breast pain

  • Ankle swelling

  • A sense of increased weight

  • Skin disorders

  • Irritability, aggressiveness, depression, inability to concentrate, libido change, lethargy, and food cravings

Differential Diagnosis

  • Depression

  • Premenstrual dysphoric disorder

  • Endometriosis

  • Uterine leiomyomas (fibroids)

  • Pregnancy

  • Anxiety disorder

  • Hypothyroidism


Diagnostic Procedures

  • Careful evaluation of the patient

  • History of symptoms


General Measures

  • Current treatment methods are mainly empiric

  • Provide support for the emotional and physical distress

  • Advise the patient to keep a daily diary of all symptoms for 2–3 months to help in evaluating the timing and characteristics of the syndrome

  • If her symptoms occur throughout the month rather than in the 2 weeks before menses, she may have depression or other mental health problems in addition to premenstrual syndrome

Specific Measures


  • Aerobic exercise

  • Reduction of caffeine, salt, and alcohol intake


  • Drugs that prevent ovulation, such as hormonal contraceptives

    • Continuous combined oral contraceptive pill or vaginal ring use

    • Depot medroxyprogesterone acetate [DMPA] 150 mg intramuscularly (every 3 months)

    • Etonogestrel subdermal (Nexplanon) progestin implant (every 3 years)

    • High-dose progestin (medroxyprogesterone acetate 20–30 mg orally daily, or GnRH agonist with "add-back" therapy, such as conjugated equine estrogen, 0.625 mg orally daily with medroxyprogesterone acetate, 2.5–5 mg orally daily)


  • First-line drug therapy includes serotonergic antidepressants (citalopram, escitalopram, fluoxetine, sertraline, venlafaxine)

  • Several serotonin reuptake inhibitors (such as fluoxetine, 20 mg orally, either daily or only on symptom days) have been shown to be effective in relieving tension, irritability, and dysphoria with few side effects

  • There are limited data to support the use of calcium, vitamin D, and vitamin B6 supplementation

  • There is ...

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