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Results from an abnormality in the platelet glycoprotein IIb/IIIa receptor on the platelet membrane
Glycoprotein IIb/IIIa is the fibrinogen receptor critical for linking platelets during initial platelet aggregation/platelet plug formation
Inheritance is autosomal recessive
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Platelet transfusions when necessary
Desmopressin acetate (DDAVP), antifibrinolytic agents, and recombinant human activated factor VII also have been used successfully