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Clinical trials have suggested an increase in all-cause mortality with high dose (greater than 400 international units/day) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and result in bleeding in patients taking oral anticoagulants.

Lloret  A  et al. The effectiveness of vitamin E treatment in Alzheimer's disease. Int J Mol Sci. 2019;20:879.
[PubMed: 30781638]
Okebukola  PO  et al. Vitamin E supplementation in people with cystic fibrosis. Cochrane Database Syst Rev. 2017;3:CD009422.
[PubMed: 28262916]  

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