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About 10% of lymphomas present in the head and neck. Multiple rubbery nodes, especially in young adults or in patients who have AIDS, are suggestive of lymphoma. A thorough physical examination may demonstrate other sites of nodal or organ involvement. FNA biopsy may be diagnostic, but open biopsy is often required to determine architecture and an appropriate treatment course.

Cabeçadas  J  et al. Lymphomas of the head and neck region: an update. Virchows Arch. 2019;474:649.
[PubMed: 30778677]  
Payabvash  S  et al. Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis. Neuroradiology. 2019;61:897.
[PubMed: 31175398]  

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