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Preeclampsia-Eclampsia

Gestational hypertension is defined as blood pressure of ≥ 140/90 mm Hg systolic or > 90 mm

Hg diastolic after 20 weeks of gestation.

Gestational hypertension may be present in the absence of proteinuria.

Like preeclampsia-eclampsia without severe features, gestational hypertension is managed by delivery.

Maternal Hepatitis B & C Carrier State

There is one open-label, phase 1 study of pregnant women with hepatitis C treated with ledipasvir-sofosbuvir for 12 weeks starting in the second trimester.

Although the study was small (nine participants), ledipasvir-sofosbuvir was safe and effective at the standard dose.

Intrahepatic Cholestasis of Pregnancy

The use of ursodeoxycholic acid is not recommended for the treatment of intrahepatic cholestasis of pregnancy; a randomized controlled trial did not find that ursodeoxycholic acid reduced symptoms and morbidity for intrahepatic cholestasis of pregnancy.

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