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For further information, see CMDT Part 34-05: Yaws (Frambesia)
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A contagious disease largely limited to tropical regions that is caused by Treponema pallidum subspecies pertenue
Acquired by direct nonsexual contact, usually in childhood, although it may occur at any age
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Characterized by granulomatous lesions of the skin, mucous membranes, and bone
The "mother yaw," a painless papule that later ulcerates, appears 3–4 weeks after exposure
Regional lymphadenopathy is usually present
Secondary lesions that are raised papillomas and papules
Painful ulcerated lesions on the soles are called "crab yaws" because of the resulting gait
Late gummatous lesions may occur, with associated tissue destruction involving large areas of skin and subcutaneous tissues
Late effects of yaws may be confused with similar changes occurring in leprosy and include
Bone change
Shortening of digits
Contractures
Central nervous system, cardiac, or other visceral involvement is rare
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If untreated, may lead to chronic disability and disfigurement
Penicillin, 2.4 million units of benzathine penicillin G intramuscularly is generally curative in any stage of the non–sexually transmitted treponematoses
In cases of penicillin hypersensitivity, tetracycline, 500 mg orally four times a day for 10–14 days, is the recommended alternative