Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 14-06: Congenital Disorders of Platelet Function + Key Features Download Section PDF Listen +++ ++ Group of mild bleeding disorders caused by defects in release of alpha or dense (delta) platelet granules, or both + Clinical Findings Download Section PDF Listen +++ ++ Variable bleeding, ranging from spontaneous to mild and trauma-related bruising to postoperative bleeding Bleeding due to defective platelets is classically mucocutaneous, but is not limited to mucocutaneous surfaces + Diagnosis Download Section PDF Listen +++ ++ Prolonged bleeding time Platelet aggregation studies characteristically show platelet dissociation following an initial aggregatory response Electron microscopy confirms diagnosis + Treatment Download Section PDF Listen +++ ++ Mainstay of treatment (including periprocedural prophylaxis) is transfusion of normal platelets Desmopressin acetate (DDAVP), antifibrinolytic agents, and recombinant human activated factor VII also have been used successfully