Riboflavin Deficiency

Almost always occurs in combination with deficiencies of other vitamins

Caused by dietary inadequacy, interactions with a variety of medications, alcoholism, and other causes of protein-calorie undernutrition

Cheilosis, angular stomatitis, glossitis

Seborrheic dermatitis

Weakness

Corneal vascularization

Anemia

Measure serum levels of the riboflavin-dependent enzyme erythrocyte glutathione reductase. Activity coefficients > 1.2–1.4 suggest riboflavin deficiency

Urinary riboflavin excretion and serum levels of plasma and red blood cell flavins can also be measured

Riboflavin, 5–15 mg orally once daily, until clinical findings are resolved