Pituitary, hypothalamus | Diethylstilbestrol | 1–3 mg orally daily | Gynecomastia, hot flushes, thromboembolic disease, erectile dysfunction |
| LHRH agonists Leuprolide Goserelin Triptorelin Histrelin | Daily subcutaneous injection Monthly to quarterly depot injection Monthly depot injection Annual subcutaneous implant | Erectile dysfunction, hot flushes, gynecomastia, rarely anemia |
| LHRH antagonist Degarelix | 240 mg subcutaneously initial dose, then 80 mg subcutaneously monthly | Hot flushes, weight gain, erectile dysfunction, increased liver tests |
Adrenal | Ketoconazole | 400 mg three times orally daily | Adrenal insufficiency, nausea, rash, ataxia |
| Aminoglutethimide | 250 mg four times orally daily | Adrenal insufficiency, nausea, rash, ataxia |
| Corticosteroid Prednisone | 20–40 mg orally daily | Gastrointestinal bleeding, fluid retention |
| CYP17a1 inhibitor Abiraterone | 1000 mg orally daily (with prednisone 5 mg orally twice daily) | Weight gain, fluid retention, hypokalemia, hypertension |
Testis | Orchiectomy | | Gynecomastia, hot flushes, erectile dysfunction |
Prostate cell | Antiandrogens | | |
| Flutamide | 250 mg three times orally daily | No erectile dysfunction when used alone; nausea, diarrhea |
| Bicalutamide | 50 mg orally daily | Liver, cardiac, and pulmonary toxicity |
| Enzalutamide | 160 mg orally daily | Seizures, dizziness, asthenia |
| Apalutamide | 240 mg orally daily | Fatigue, leukopenia, hyperlipidemia, hyperglycemia, hyperkalemia, seizures (rare) |
| Doralutamide | 600 mg orally twice daily | Fatigue, extremity pain, rash |
| Cytotoxic chemotherapeutic agents | | Bone marrow, skin, pulmonary, cardiac, gastrointestinal, hepatic toxicities possible |
| Docetaxel | 75 mg/m2 intravenously once on day 1 of 21-day cycle (with prednisone 10 mg orally daily) | |
| Cabazitaxel | 20 mg/m2 intravenously once on day 1 of 21-day cycle (with prednisone 10 mg orally daily) | |