Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 29-12: Niacin Deficiency + Key Features Download Section PDF Listen +++ ++ Most commonly results from alcoholism and nutrient–drug interactions Can also occur in inborn errors of metabolism Manifestations are nonspecific + Clinical Findings Download Section PDF Listen +++ ++ Common complaints Anorexia Weakness Irritability Mouth soreness Glossitis Stomatitis Weight loss More advanced deficiency results in the classic triad of pellagra: dermatitis, diarrhea, dementia Advanced pellagra can result in death + Diagnosis Download Section PDF Listen +++ ++ Diagnosis of pellagra is made clinically Niacin can be measured in serum or plasma; adult reference range is 0.50–8.45 mcg/mL + Treatment Download Section PDF Listen +++ ++ Niacin, usually given as nicotinamide, 10–150 mg orally once daily