Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 24-29: Polyneuropathies & Mononeuritis Multiplex + Key Features Download Section PDF Listen +++ ++ Axonal polyneuropathy may follow exposure to Industrial agents or pesticides, such as acrylamide, organophosphorus compounds, hexacarbon solvents, methyl bromide, and carbon disulfide Metals, such as arsenic, thallium, mercury, and lead High doses of such certain medications, such as phenytoin, amiodarone, perhexiline, isoniazid, nitrofurantoin, vincristine, and pyridoxine Bulbar and distal sensorimotor polyneuropathy may follow diphtheria + Clinical Findings Download Section PDF Listen +++ ++ Diphtheritic neuropathy Results from a neurotoxin released by the causative organism and is common in many areas Palatal weakness may develop 2–4 weeks after infection of the throat Infection of the skin may similarly be followed by focal weakness of neighboring muscles Disturbances of visual accommodation may occur about 4–5 weeks after infection Distal sensorimotor demyelinating polyneuropathy may occur after 1–3 months + Diagnosis Download Section PDF Listen +++ ++ Detailed occupational, environmental, and medical histories and recognition of clusters of cases are important in suggesting the diagnosis + Treatment Download Section PDF Listen +++ ++ Prevent further exposure to the causal agent Isoniazid neuropathy is prevented by pyridoxine supplementation