Chloroquine-sensitive Plasmodium falciparum and Plasmodium malariae infections | Chloroquine phosphate, 1 g at 0 hours, followed by 500 mg at 6, 24, and 48 hours or– Chloroquine phosphate, 1 g at 0 hours and 24 hours, then 0.5 g at 48 hours | |
Plasmodium vivax and Plasmodium ovale infections | Chloroquine (as above), then (if G6PD normal) primaquine, 30-mg base daily for 14 days or tafenoquine 300 mg once | For infections from Indonesia, Papua New Guinea, and other areas with suspected resistance: therapies listed for uncomplicated chloroquine-resistant P falciparum plus primaquine |
Uncomplicated infections with chloroquine-resistant P falciparum | Coartem (artemether 20 mg, lumefantrine 120 mg), four tablets twice daily for 3 days or– Malarone, four tablets (total of 1 g of atovaquone, 400 mg of proguanil) daily for 3 days or– Quinine sulfate, 650 mg three times daily for 3–7 days Plus one of the following (when quinine given for < 7 days) Doxycycline, 100 mg twice daily for 7 days or– Clindamycin, 600 mg twice daily for 7 days | Mefloquine, 15 mg/kg once or 750 mg, then 500 mg in 6–8 hours or– Dihydroartemisinin-piperaquine2 (dihydroartemisinin 40 mg, piperaquine 320 mg), 4 tablets daily for 3 days or– ASAQ2 (artesunate 100 mg, amodiaquine 270 mg), two tablets daily for 3 days |
Severe or complicated infections with P falciparum | Artesunate 2.4 mg/kg intravenously every 12 hours for 1 day, then daily3,6 | Quinidine gluconate,4–6 10 mg/kg intravenously over 1–2 hours, then 0.02 mg/kg intravenously/min or– Quinidine gluconate,4–6 15 mg/kg intravenously over 4 hours, then 7.5 mg/kg intravenously over 4 hours every 8 hours or– Quinine dihydrochloride,2,4–6 20 mg/kg intravenously over 4 hours, then 10 mg/kg intravenously every 8 hours or– Artemether,2,6 3.2 mg/kg intramuscularly, then 1.6 mg/kg/day intramuscularly |