Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 33-28: Granuloma Inguinale + Key Features Download Section PDF Listen +++ ++ A chronic, relapsing granulomatous anogenital infection caused by Calymmatobacterium (Donovania) granulomatis The incubation period is 8 days to 12 weeks + Clinical Findings Download Section PDF Listen +++ ++ Onset is insidious Lesions occur on the skin or mucous membranes of the genitalia or perineal area Lesions are relatively painless, infiltrated nodules that soon slough A shallow, sharply demarcated ulcer forms, with a beefy-red friable base of granulation tissue The lesion spreads by contiguity The advancing border has a characteristic rolled edge of granulation tissue Superinfection with spirochete-fusiform organisms is common The ulcer then becomes purulent, painful, foul smelling, and extremely difficult to treat + Diagnosis Download Section PDF Listen +++ ++ Culture + Treatment Download Section PDF Listen +++ ++ Recommended regimens Doxycycline, 100 mg twice daily orally or Azithromycin, 1 g once weekly orally or Ciprofloxacin, 750 mg twice daily orally or Erythromycin, 500 mg four times daily orally Treatment duration is 3 weeks or until all lesions have healed