Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 9-28: Alveolar Hemorrhage Syndromes + Key Features Download Section PDF Listen +++ ++ Idiopathic recurrent alveolar hemorrhage and rapidly progressive glomerulonephritis Mediated by anti-glomerular basement membrane antibodies Occurs mainly in men who are in their 30s and 40s + Clinical Findings Download Section PDF Listen +++ ++ Hemoptysis is the usual presenting symptom However, pulmonary hemorrhage may be occult Dyspnea, cough, hypoxemia, and diffuse bilateral alveolar infiltrates are typical features Iron deficiency anemia and microscopic hematuria are usually present + Diagnosis Download Section PDF Listen +++ ++ Based on characteristic linear IgG deposits detected by immunofluorescence in glomeruli or alveoli and on the presence of anti-glomerular basement membrane antibody in serum + Treatment Download Section PDF Listen +++ ++ Combinations of immunosuppressive drugs (initially methylprednisolone, 30 mg/kg intravenously over 20 minutes every other day for three doses, followed by daily oral prednisone, 1 mg/kg/day; with cyclophosphamide, 2 mg/kg by mouth per day) and plasmapheresis have yielded excellent results