Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 9-27: Pulmonary Vasculitis + Key Features Download Section PDF Listen +++ ++ Idiopathic vasculitis of small- and medium-sized arteries seen in patients with symptoms of asthma Affects multiple organ systems, most commonly skin and lung, but heart, gastrointestinal tract, and peripheral nerves may also be affected + Clinical Findings Download Section PDF Listen +++ ++ Marked peripheral eosinophilia Chest radiographic findings range from transient opacities to pulmonary nodules + Diagnosis Download Section PDF Listen +++ ++ Histologic features include fibrinoid necrotizing epithelioid and eosinophilic granulomas + Treatment Download Section PDF Listen +++ ++ Usually requires corticosteroids (prednisone, 1 mg/kg/day, tapering over 3–6 months) and cyclophosphamide (1–2 mg/kg/day, until complete remission is obtained and then tapered slowly) Replace cyclophosphamide with methotrexate or azathioprine for maintenance therapy