| Antibiotic Agents2 |
| Amikacin 2.5% (fortified) solution | Compounding pharmacy | | |
| Azithromycin (AzaSite) | $247.45/2.5 mL | 1 drop two times daily for 2 days, then once daily for 5 days | Bacterial conjunctivitis |
| Bacitracin 500 units/g ointment (various)3 | $118.44/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac or to eyelids three to four times daily for 7–10 days | Bacterial conjunctivitis, blepharitis, sty |
| Bacitracin/Polymyxin ointment (Polysporin, AK-Poly) | $25.70/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac and then three to four times daily, then as required | Corneal abrasion Following corneal foreign body removal |
| Besifloxacin ophthalmic suspension, 0.6% (Besivance) | $215.42/5 mL | 1–2 drops every 2 hours while awake for 2 days, then every 4 hours for 5 days 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Cefazolin 5–10% (fortified) solution | Compounding pharmacy | | |
| Ceftazidime 5% (fortified) solution | Compounding pharmacy | | |
| Cefuroxime 5% (fortified) solution | Compounding pharmacy | | |
| Chloramphenicol 1% ointment4 | Compounding pharmacy | | |
| Chloramphenicol 0.5% solution4 | Compounding pharmacy | | |
| Ciprofloxacin HCl 0.3% solution (Ciloxan) | $10.20/5 mL | 1–2 drops every 2 hours while awake for 2 days, then every 4 hours for 5 days 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Ciprofloxacin HCl 0.3% ointment | $257.23/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac three times daily for 2 days, then two times daily for 5 days | Bacterial conjunctivitis |
| Erythromycin 0.5% ointment (various)5 | $17.96/3.5 g | 1-cm ribbon up to six times daily (depending on severity of infection) | Bacterial infection of the eye |
| Fusidic acid 1% gel (Fucithalmic) | Not available in United States | 1 drop two times daily | Bacterial conjunctivitis, blepharitis, sty, keratitis |
| Gatifloxacin 0.5% solution (Zymaxid) | $118.16/2.5 mL | 1 drop every 2 hours while awake, up to eight times on day 1, then two to four times daily while awake, days 2–7 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Gentamicin sulfate 0.3% solution (various) | $19.18/5 mL | 1–2 drops every 4 hours up to 2 drops every hour for severe infections | Ocular surface infection |
| Gentamicin sulfate 0.3% ointment (various) | $35.44/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac two to three times daily | Ocular surface infection |
| Gentamicin sulfate 1.5% (fortified preparation) | Compounding pharmacy | 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial keratitis |
| Levofloxacin 0.5% solution (various) | $74.76/5 mL | 1–2 drops every 2 hours while awake for 2 days (maximum eight times per day), then every 4 hours for 5 days (maximum four times per day) 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Moxifloxacin 0.5% solution (Vigamox) | $167.35/3 mL | 1 drop three times daily for 7 days 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Neomycin/Polymyxin B/Gramicidin (Neosporin) | $61.26/10 mL | 1–2 drops every 4 hours for 7–10 days or more frequently, as required | Ocular surface infection |
| Norfloxacin 0.3% solution | Not available in United States | 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Ocular surface infection Bacterial keratitis |
| Ofloxacin 0.3% solution (Ocuflox) | $20.94/5 mL | 1–2 drops every 2–4 hours for 2 days, then four times daily for 5 days 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial conjunctivitis Bacterial keratitis |
| Polymyxin B 10,000 U/mL/Trimethoprim sulfate 1 mg/mL (Polytrim)6 | $12.87/10 mL | 1 drop every 3 hours for 7–10 days (maximum of 6 doses per day) | Ocular surface infection |
| Propamidine isethionate 0.1% solution | Not available in the United States | 1–2 drops every 2–4 hours for 2 days, then four times daily for 5 days | Ocular surface infection (including Acanthamoeba keratitis) |
| Propamidine isethionate 0.1% ointment | Not available in the United States | Apply small amount (0.5 inch) into lower conjunctival sac up to four times daily | |
| Sulfacetamide sodium 10% solution (various) | $55.65/15 mL | 1 or 2 drops every 2–3 hours initially; taper by increasing time intervals as condition responds; usual duration 7–10 days | Bacterial infection of the eye |
| Sulfacetamide sodium 10% ointment (various) | $65.86/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac once every 3–4 hours and at bedtime; taper by increasing time intervals as condition responds; usual duration 7–10 days | Bacterial infections of the eye |
| Tobramycin 0.3% solution (various) | $14.10/5 mL | 1–2 drops every 4 hours for a mild to moderate infection or hourly until improvement (then reduce prior to discontinuation) for a severe infection | |
| Tobramycin 1.5% (fortified) solution | Compounding pharmacy | 1 drop every hour during the day and every 2 hours during the night for 48 hours, then gradually reducing | Bacterial keratitis |
| Tobramycin 0.3% ointment (Tobrex) | $257.23/3.5 g | Apply small amount (0.5 inch) into lower conjunctival sac two to three times daily for a mild to moderate infection or every 3–4 hours until improvement (then reduce prior to discontinuation) for a severe infection | |
| Antifungal Agents |
| Amphotericin 0.1–0.5% solution | Compounding pharmacy | | |
| Natamycin 5% suspension (Natacyn) | $395.00/15 mL | 1 drop every 1–2 hours initially | Fungal blepharitis, conjunctivitis, keratitis |
| Voriconazole 1% solution | Compounding pharmacy | | |
| Antiviral Agents |
| Acyclovir 3% ointment (Zovirax) | Not available in United States | Five times daily | Herpes simplex virus keratitis |
| Ganciclovir 0.15% gel (Zirgan) | $446.81/5 g | Five times daily | Herpetic keratitis |
| Trifluridine 1% solution (Viroptic) | $178.28/7.5 mL | 1 drop onto cornea every 2 hours while awake for a maximum daily dose of 9 drops until resolution occurs; then an additional 7 days of 1 drop every 4 hours while awake (minimum five times daily) | Herpes simplex virus keratitis |
| Anti-Inflammatory Agents |
| Antihistamines7 |
| Emedastine difumarate 0.05% solution (Emadine) | Not available in the United States | 1 drop four times daily | Allergic eye disease |
| Levocabastine (Livostin) | Not available in United States | 1 drop twice daily | |
| Mast cell stabilizers | |
| Cromolyn sodium 4% solution (Crolom) | $37.25/10 mL | 1 drop four to six times daily | |
| Lodoxamide tromethamine 0.1% solution (Alomide) | $205.28/10 mL | 1 or 2 drops four times daily (up to 3 months) | |
| Nedocromil sodium 2% solution (Alocril) | $256.58/5 mL | 1 drop twice daily | |
| Pemirolast potassium 0.1% solution (Alamast) | Not available in the United States | 1 drop four times daily | |
| Combined antihistamines and mast cell stabilizers | |
| Alcaftadine 0.25% ophthalmic solution (Lastacaft) | $270.47/3 mL | 1 drop once daily | |
| Azelastine HCl 0.05% ophthalmic solution (Optivar) | $102.90/6 mL | 1 drop two to four times daily (up to 6 weeks) | |
| Bepotastine besilate 1.5% solution (Bepreve) | $528.11/10 mL | 1 drop twice daily | |
| Epinastine hydrochloride 0.05% ophthalmic solution (Elestat) | $106.95/5 mL | 1 drop twice daily (up to 8 weeks) | |
| Ketotifen fumarate 0.025% solution (Zaditor) | OTC $7.79/5 mL | 1 drop two to four times daily | |
| Olopatadine hydrochloride 0.1% solution (Patanol) | $13.80/5 mL | 1 drop twice daily | |
| Nonsteroidal anti-inflammatory agents8 |
| Bromfenac 0.09% solution (Xibrom) | $/1.7 mL | 1 drop to operated eye twice daily beginning 24 hours after cataract surgery and continuing through first 2 postoperative weeks | Treatment of postoperative inflammation following cataract extraction |
| Diclofenac sodium 0.1% solution (Voltaren) | $17.50/5 mL | 1 drop to operated eye four times daily beginning 24 hours after surgery and continuing through first 2 postoperative weeks. | Treatment of postoperative inflammation following cataract extraction and laser corneal surgery |
| Flurbiprofen sodium 0.03% solution (various) | $43.20/2.5 mL | 1 drop every half hour beginning 2 hours before surgery; 1 drop to operated eye four times daily beginning 24 hours after cataract surgery | Inhibition of intraoperative miosis; treatment of cystoid macular edema and inflammation after cataract surgery |
| Indomethacin 1% solution (Indocid) | Not available in United States | 1 drop four times daily | Treatment of allergic eye disease, postoperative inflammation following cataract extraction and laser corneal surgery |
| Ketorolac tromethamine 0.5% solution (Acular) | $105.50/5 mL | 1 drop four times daily | Treatment of allergic eye disease, postoperative inflammation following cataract extraction and laser corneal surgery |
| Nepafenac 0.1% suspension (Nevanac) | $325.96/3 mL | 1 drop to operated eye three times daily beginning 24 hours after cataract surgery and continuing through first 2 postoperative weeks | Treatment of postoperative inflammation following cataract extraction |
| Corticosteroids9 |
| Dexamethasone sodium phosphate 0.1% solution (various) | $21.10/5 mL | 1 or 2 drops as often as indicated by severity; use every hour during the day and every 2 hours during the night in severe inflammation; taper off as inflammation decreases | Treatment of steroid-responsive inflammatory conditions |
| Dexamethasone sodium phosphate 0.05% ointment | Compounding pharmacy | Apply thin coating on lower conjunctival sac three or four times daily | |
| Fluorometholone 0.1% suspension (various)10 | $170.50/10 mL | 1 or 2 drops as often as indicated by severity; use every hour during the day and every 2 hours during the night in severe inflammation; taper off as inflammation decreases | |
| Fluorometholone 0.25% suspension (FML Forte)10 | $384.97/10 mL | 1 drop two to four times daily | |
| Fluorometholone 0.1% ointment (FML S.O.P.) | $183.31/3.5 g | Apply thin coating on lower conjunctival sac three or four times daily | |
| Loteprednol etabonate 0.5% (Lotemax) | $512.86/10 mL | 1 or 2 drops four times daily | |
| Prednisolone acetate 0.12% suspension (Pred Mild) | $366.64/10 mL | 1 or 2 drops as often as indicated by severity of inflammation; use every hour during the day and every 2 hours during the night in severe inflammation; taper off as inflammation decreases | |
| Prednisolone sodium phosphate 0.125% solution | Compounding pharmacy | | |
| Prednisolone acetate 1% suspension (various) | $105.60/10 mL | 2 drops four times daily | |
| Prednisolone sodium phosphate 1% solution (various) | $63.25/10 mL | 1–2 drops two to four times daily | |
| Immunomodulators |
| Cyclosporine 0.05% emulsion (Restasis) 0.4 mL/container | $351.35/30 containers | 1 drop twice daily | Dry eyes and severe allergic eye disease |
| Tacrolimus 0.1% ointment | $260.45/30 g tube | Not yet established (no label to support) | Severe allergic eye disease; no indication in United States |
| Glaucoma and Ocular Hypertension Agents |
| Sympathomimetics |
| Apraclonidine HCl 0.5% solution (Iopidine) | $86.77/5 mL | 1 drop three times daily | Reduction of intraocular pressure; expensive; reserve for treatment of resistant cases |
| Apraclonidine HCl 1% solution (Iopidine) | $33.27/unit dose | 1 drop 1 hour before and immediately after anterior segment laser surgery | To control or prevent elevations of intraocular pressure after laser trabeculoplasty or iridotomy |
| Brimonidine tartrate 0.2% solution (Alphagan, Alphagan P [benzalkonium chloride-free]) | $17.50/5 mL | 1 drop two or three times daily | Reduction of intraocular pressure |
| Beta-adrenergic blocking agents |
| Betaxolol HCl 0.5% solution (Betoptic) and 0.25% suspension (Betoptic S)11 | 0.5%: $117.91/10 mL 0.25%: $372.64/10 mL | 1 drop twice daily | Reduction of intraocular pressure |
| Carteolol HCl 1% and 2% solution (various, Teoptic)12 | 1%: $40.10/10 mL | 1 drop twice daily | |
| Levobunolol HCl 0.25% and 0.5% solution (Betagan)13 | 0.5%: $21.49/5 mL | 1 drop once or twice daily | |
| Metipranolol HCl 0.3% solution (OptiPranolol)13 | $29.67/5 mL | 1 drop twice daily | |
| Timolol 0.25% and 0.5% solution (Betimol)13 | 0.5%: $169.28/5 mL | 1 drop once or twice daily | |
| Timolol maleate 0.25% and 0.5% solution (Istalol, Ocudose [preservative-free], Timoptic) and 0.1%, 0.25%, and 0.5% gel (Timoptic-XE, Timoptic GFS)13 | 0.5% solution: $6.03/5 mL 0.5% gel: $217.27/5 mL | 1 drop once or twice daily | |
| Miotics |
| Pilocarpine HCl 1–4% solution14 | 1% solution: $94.81/15 mL | 1 drop up to four times daily for elevated intraocular pressure | Reduction of intraocular pressure, treatment of acute or chronic angle-closure glaucoma, and pupillary constriction |
| Carbonic anhydrase inhibitors |
| Brinzolamide 1% suspension (Azopt) | $390.41/10 mL | 1 drop three times daily | Reduction of intraocular pressure |
| Dorzolamide HCl 2% solution (Trusopt) | $40.79/10 mL | 1 drop three times daily | |
| Prostaglandin analogs |
| Bimatoprost 0.03% solution (Lumigan) | $154.30/3 mL | 1 drop once daily at night | Reduction of intraocular pressure |
| Latanoprost 0.005% solution (Xalatan, Monopost [preservative-free]) | $15.00/2.5 mL (Monopost not available in United States) | 1 drop once or twice daily at night | |
| Latanoprostene bunod 0.024% solution (Vyzulta) | $292.70/2.5 mL | 1 drop daily at night | |
| Tafluprost 0.0015% solution (Saflutan [preservative-free], Taflotan, Zioptan [preservative-free]) | $255.61/30 units (Saflutan not available in United States) | 1 drop once daily at night | |
| Travoprost 0.004% solution (Travatan, Travatan Z [benzalkonium chloride-free]) | $198.36/2.5 mL | 1 drop once daily at night | |
| Unoprostone isopropyl 0.15% solution (Rescula) | $153.84/5 mL | 1 drop twice daily | |
| Rho kinase inhibitor |
| Netarsudil ophthalmic solution 0.02% (Rhopressa) | $376.48/2.5 mL | 1 drop daily in the evening | Reduction of intraocular pressure |
| Combined preparations |
| Bimatoprost 0.03% and timolol 0.5% (Ganfort) | Not available in United States | 1 drop daily in the morning | Reduction of intraocular pressure |
| Brimonidine 0.2% and timolol 0.5% (Combigan) | $222.18/10 mL | 1 drop twice daily | |
| Brimonidine 0.2% and brinzolamide 1% (Simbrinza) | $206.02/8 mL | 1 drop three times a day | |
| Brinzolamide 1% and timolol 0.5% (Azarga) | Not available in United States | 1 drop twice daily | |
| Dorzolamide 2% and timolol 0.5% (Cosopt, Cosopt PF [preservative-free]) | $67.49/10 mL | 1 drop twice daily | |
| Latanoprost 0.005% and timolol 0.5% (Xalacom) | Not available in United States | 1 drop daily in the morning | |
| Tafluprost 0.0015% and timolol 0.5% (Taptiqom [preservative-free]) | Not available in United States | 1 drop daily | |
| Travoprost 0.004% and timolol 0.5% (DuoTrav) | Not available in United States | 1 drop daily | |