Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ For further information, see CMDT Part 17-08: Carcinoma of the Male Breast + Key Features Download Section PDF Listen +++ ++ Rare; average age, 70 yr Hormonal influences likely play an important role + Clinical Findings Download Section PDF Listen +++ ++ Painless lump beneath the areola, usually found after age 50 Nipple discharge, retraction, or ulceration Gynecomastia not uncommonly precedes or accompanies male breast cancer Increased incidence of breast cancer in men with prostate cancer Examination usually shows a hard, ill-defined, nontender mass beneath the nipple or areola Cancer staging is the same in men as in women + Diagnosis Download Section PDF Listen +++ ++ Biopsy is required to confirm diagnosis Differential diagnosis Gynecomastia Metastatic cancer from another site (eg, prostate) Fatty breast enlargement of obesity + Treatment Download Section PDF Listen +++ ++ Modified radical mastectomy in operable patients Irradiation for localized, symptomatic metastases to skin, lymph nodes, or skeleton Adjuvant chemotherapy is used for the same indications as in female breast cancer Tamoxifen, 20 mg orally once daily, for advanced-stage male breast cancer Aromatase inhibitors There are little data regarding the use in men However, they are being used more frequently Castration produces regression in 60–70% 5-year survival rate for node-positive disease: ~69% 5-year survival rate for node-negative disease: ~88%